Natazia® - First COC with Estradiol Valerate and Dienogest
Available by prescription only.
Natazia (estradiol valerate and estradiol valerate/dienogest) is a combination oral contraceptive (COC) indicated for use by women to prevent pregnancy.
IMPORTANT SAFETY INFORMATION ABOUT NATAZIA, INCLUDING BOXED WARNING
What is NATAZIA® prescribed for?
Natazia is a birth control pill indicated for the prevention of pregnancy.
NATAZIA has not been studied in women who are obese (body mass index >30).
Who should not take Natazia?
Do not use Natazia if you smoke and are over age 35. Smoking increases your risk of serious side effects from the Pill, which can be life-threatening, including blood clots, stroke, or heart attack. This risk increases with age and number of cigarettes smoked.
Do not use Natazia if you have or have had blood clots, certain cancers, history of heart attack or stroke, or if you are or may be pregnant.
What are the most serious risks of taking birth control pills?
Natazia increases the risk of serious conditions including blood clots, stroke, and
heart attack. The risk of blood clots is highest during the first year of use.
Call your healthcare provider right away if you have:
- Persistent leg pain; sudden shortness of breath; sudden blindness, partial or complete; severe pain in your chest; sudden, severe headache unlike your usual headaches; weakness or numbness in an arm or leg, or trouble speaking; yellowing of the skin or eyes
What are the most common side effects?
In clinical trials, the most common side effects were headache/migraine, irregular
periods, breast pain or tenderness, nausea/vomiting, acne, and weight gain.
Tell your healthcare provider about all medicines and herbal products you take including daily long-term treatment for chronic conditions such as seizures or cardiovascular disease.
Natazia does not protect against HIV infection (AIDS) or other STDs.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information about Natazia, including boxed warning.
Bayer®, the Bayer Cross®, and Natazia® are trademarks of Bayer. All other trademarks are the property of their respective owners.








